Neutrophils Contribute to RBC Alloantibody Production
نویسندگان
چکیده
منابع مشابه
886 Alloantibody Production and Histoincom
Despite intensive investigation, the essential mechanisms of allograft rejection or tolerance have remained obscure. Although there is now no doubt that juvenile as well as adult individuals respond to foreign tissue grafts with production of serum antibodies against the alloantigens (isoantigens) of the donor, the possible roles of such antibodies in graft rejection continue to be controversia...
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Previous studies have shown that the pro-inflammatory cytokine IL-1β has a crucial role in host defenses against group B streptococcus (GBS), a frequent human pathogen, by recruiting neutrophils to infection sites. We examined here the cell types and mechanisms involved in IL-1β production during infection. Using a GBS-induced peritonitis model in mice, we first found that a large proportion of...
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Atherosclerosis is a low-grade inflammatory disease involving leukocytes, lipids, and glucose leading to endothelial dysfunction. Since activation of neutrophils by triglycerides and glucose has been described in vitro, we hypothesized that the postprandial phase is an inflammatory state affecting leukocytes, possibly contributing to endothelial dysfunction. We measured postprandial blood leuko...
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We have examined whether T cell stimulation by direct or indirect pathways contributes to alloantibody production by B cells after major histocompatibility complex (MHC)-disparate skin graft rejection in mice. Experiments were performed using normal mice, MHC class II-deficient mice, MHC class II-deficient mice with an intact peripheral CD4+ cell population (due to expression of class II antige...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v126.23.3437.3437